Calcium Phosphate Bone Cements for Local Vancomycin Delivery
Materials Science and Engineering C
2015
Dagnija Loča,
Marina Putniņa,
Jānis Ločs,
Anastasija Smirnova,
Zilgma Irbe
Among calciumphosphate biomaterials, calciumphosphate bone cements (CPCs) have attracted increased attention
because of their ability of self-setting in vivo and injectability, opening the new opportunities for minimally
invasive surgical procedures. However, any surgical procedure carries potential inflammation and bone infection
risks, which could be prevented combining CPC with anti-inflammatory drugs, thus overcoming the disadvantages
of systemic antibiotic therapy and controlling the initial burst and total release of active ingredient
Keywords
Calcium phosphate cement, PLA, Vancomycin, Microspheres, Drug delivery
DOI
10.1016/j.msec.2014.12.075
Hyperlink
http://www.sciencedirect.com/science/article/pii/S092849311400873X
Loča, D., Sokolova, M., Ločs, J., Smirnova, A., Irbe, Z. Calcium Phosphate Bone Cements for Local Vancomycin Delivery. Materials Science and Engineering C, 2015, Vol.49, pp.106-113. ISSN 0928-4931. Available from: doi:10.1016/j.msec.2014.12.075
Publication language
English (en)