Synthesis of a New Type of Carbonic Anhydrases Inhibitors
2020
Aleksandrs Pustenko

Defending
30.09.2020. 14:00, Rīgas Tehniskās universitātes Materiālzinātnes un lietišķās ķīmijas fakultātē, Rīgā, Paula Valdena ielā 3, 272. auditorijā.

Supervisor
Raivis Žalubovskis

Reviewers
Jeļena Kirilova, Kaspars Traskovskis, Jean-Yves Winum

The Doctoral Thesis has been prepared as a thematically united collection of scientific publications. It consists of a summary and five scientific publications. Publications have been written in English, their total volume is 39 pages. A new, selective class of CA IX and CA XII inhibitors – 3H-1,2-benzoxathiepine 2,2-dioxides, has been found. A series of 3H-1,2-benzoxathiepine 2,2-dioxide triazolyl, acylamino and aryl derivatives was synthesized. We discovered that furagin, a clinically used antibacterial agent, is a selective inhibitor of CA IX and CA XII. Developing this concept, we synthesized a series of imidazolidine-2,4-dione derivatives. Inhibitory activity on relevant human CA isoforms (I, II, IX, and XII) was determined for all products synthesized within the scope of the Doctoral Thesis.


Keywords
ogļskābes anhidrāzes

Pustenko, Aleksandrs. Synthesis of a New Type of Carbonic Anhydrases Inhibitors. PhD Thesis. Rīga: [RTU], 2020. 102 p.

Publication language
Latvian (lv)
The Scientific Library of the Riga Technical University.
E-mail: uzzinas@rtu.lv; Phone: +371 28399196