Applications of Purine Ring Opening in the Synthesis of Imidazole, Pyrimidine, and New Purine Derivatives

2021
Kristaps Leškovskis, Jānis Miķelis Zaķis, Irina Novosjolova, Māris Turks

The Cover Feature shows the essence of purine ring opening pathways. Electrophilic activation of purine by pulling its electron density from N(1) or N(7) and subsequent nucleophile attack ensures the ring-opening of the pyrimidine or imidazole part of the parent heterocycle. The obtained products can be used as such or submitted to further rearrangements and cyclizations. This methodology is a useful addition to the synthetic toolbox of heterocyclic chemistry.

Keywords
Fused ring systems, Imidazoles, Nucleobases, Nucleophilic addition, Ring opening
DOI
10.1002/ejoc.202101108
Hyperlink
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202101108

Leškovskis, K., Zaķis, J., Novosjolova, I., Turks, M. Applications of Purine Ring Opening in the Synthesis of Imidazole, Pyrimidine, and New Purine Derivatives [online]. Wiley Online Library 2021. Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202101108. Available from: doi:10.1002/ejoc.202101108

Publication language
English (en)