Cover Feature: Applications of Purine Ring Opening in the Synthesis of Imidazole, Pyrimidine, and New Purine Derivatives (Eur. J. Org. Chem. 36/2021)

European Journal of Organic Chemistry 2021
Kristaps Leškovskis, Jānis Miķelis Zaķis, Irina Novosjolova, Māris Turks

The Cover Feature shows the essence of purine ring opening pathways. Electrophilic activation of purine by pulling its electron density from N(1) or N(7) and subsequent nucleophile attack ensures the ring-opening of the pyrimidine or imidazole part of the parent heterocycle. The obtained products can be used as such or submitted to further rearrangements and cyclizations. This methodology is a useful addition to the synthetic toolbox of heterocyclic chemistry. More information can be found in the Review by I. Novosjolova, M. Turks et al.

DOI
10.1002/ejoc.202101108
Hyperlink
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202101108

Leškovskis, K., Zaķis, J., Novosjolova, I., Turks, M. Cover Feature: Applications of Purine Ring Opening in the Synthesis of Imidazole, Pyrimidine, and New Purine Derivatives (Eur. J. Org. Chem. 36/2021). European Journal of Organic Chemistry, 2021, Vol. 36, pp.5018-5018. ISSN 1434-193X. e-ISSN 1099-0690. Available from: doi:10.1002/ejoc.202101108

Publication language
English (en)