Octacalcium Phosphate Biomaterials: Formation Process, Modification and Application
2024
Ilijana Kovrlija

Defending
06.09.2024. 14:00, Paula Valdena ielā 3/7, 272.auditorijā

Supervisor
Jānis Ločs, Dagnija Loča

Reviewers
Māris Turks, agnese Brangule, Sabine van Rijt

Within the present work, the synthesis methodology and upscaling of octacalcium phosphate (OCP) production from low-temperature α-tricalcium phosphate (α-TCP) have been optimized, and a comprehensive analysis profile of the obtained OCP has been established. To ultimately utilize the data from the physicochemical analysis, an in silico model capable of identifying the production stage of OCP has been designed. The developed OCP has been applied in two approaches: as a doxorubicin hydrochloride (DOX) drug delivery system for the treatment of osteosarcoma and as a protective coating against corrosion for titanium implants. The doxorubicin-octacalcium phosphate (DOX-OCP) drug delivery system was characterized, and the in vitro drug release and biological effects on MG63 (cancer cells) and MC3T3-E1 (normal cells) were studied. Sodium alginate/octacalcium phosphate (Alg/OCP) composite coatings were developed, and their electrochemical behavior on titanium alloys in inflammatory conditions was assessed. The Doctoral Thesis has been written as a collection of articles. It consists of a summary in Latvian and English and five SCI publications. Each summary contains 15 figures and 1 table, followed by 5 appendices, totaling in 173 pages, including electronically available supplementary information.


Keywords
amorphous calcium phosphate; alginate/octacalcium phosphate; doxorubicin-loaded octacalcium phosphate
DOI
10.7250/9789934371066

Kovrlija, Ilijana. Octacalcium Phosphate Biomaterials: Formation Process, Modification and Application. PhD Thesis. Rīga: [RTU], 2024. 175 p.

Publication language
English (en)
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