Synthesis of Silver-Doped Hydroxyapatite Scaffolds for Controlled Drug Delivery

Abstracts of the 52nd International Scientific Conference of Riga Technical University : Section: Material Science and Applied Chemistry 2011
Arita Dubņika, Dagnija Loča, Līga Bērziņa-Cimdiņa, Anete Miglāne

Drug delivery is one of the important considerations in drug development and therapeutics. Controlled drug delivery systems (DDS) based on porous CaP ceramics have advantage of providing constant and continuous drug levels with limited side effects. Synthetic hydroxyapatite (HAp) is one of the most perspective materials because of its biocompatibility, osteoconductivity and bioactivity. To provide implant material with antibacterial properties HAp can be modified with various metal ions such as Pb2+, Cd2+, Cu2+, Mn2+, Ag+ etc. Silver compounds are highly antimicrobial due to their antiseptic properties. The objective of the current study was to synthesize Ag(I) doped hydroxyapatite scaffolds, scaffold modification with gentamicin sulphate and lidocaine hydrochloride and evaluation of HAp/drug composite properties.

Atslēgas vārdi
Hydroxyapatite, Silver, drug delivery

Dubņika, A., Loča, D., Bērziņa-Cimdiņa, L., Miglāne, A. Synthesis of Silver-Doped Hydroxyapatite Scaffolds for Controlled Drug Delivery. No: Abstracts of the 52nd International Scientific Conference of Riga Technical University : Section: Material Science and Applied Chemistry, Latvija, Rīga, 13.-15. oktobris, 2011. Riga: RTU Publishing House, 2011, 92.-92.lpp. ISBN 978-9934-10-181-6.

Publikācijas valoda
English (en)