Nowadays biodiesel production processes have been widely studied in laboratory and on an industrial scale with the purpose of decreasing the final cost of the desired product. In the biodiesel industry, the most widely used catalysts are alkali (NaOH, KOH and NaOCH3). These catalysts provide high efficiency in transesterification reactions, as they are of a homogeneous nature and are soluble in alcohols. However, homogeneous alkaline catalysts have one major drawback – the regeneration for reuse in biodiesel production process isn’t possible. Therefore the use of heterogeneous catalysts as an alternative for the transesterification reaction in biodiesel production could enable the development of a non-waste technology with a beneficial economic effect. This abstract summarizes the results of the rapeseed oil methanolysis process using various heterogeneous catalysts that are supported on plasma processed alumina nanopowder porous granules with a specific surface area of 50 m2/g.