The Synthesis of a New Oxazolidinone Chiral Auxiliary Based on D-Glucose

Abstracts of the Riga Technical University 53rd International Scientific Conference: Dedicated to the 150th Anniversary and the 1st Congress of World Engineers and Riga Polytechnical Institute / RTU Alumni 2012
Evija Rolava, Vitalijs Rodins, Jevgeņija Lugiņina, Sergejs Beļakovs, Māris Turks

Oxazolidinones and their derivatives have attracted attention in various areas of drug development for antibacterial activity, as protecting groups in organic synthesis. They are also used as chiral auxiliaries in asymmetric synthesis. Present work describes an optimized protocol for the synthesis of allo- and gluco-furanose-derived spirooxazolidinones and the study of the diastereoselective alkylation at α-position in resulting N-acyl compounds.

Atslēgas vārdi
Spiro-Oxazolidinone, Chiral Auxiliary, D-Glucose

Rolava, E., Rodins, V., Lugiņina, J., Beļakovs, S., Turks, M. The Synthesis of a New Oxazolidinone Chiral Auxiliary Based on D-Glucose. No: Abstracts of the Riga Technical University 53rd International Scientific Conference: Dedicated to the 150th Anniversary and the 1st Congress of World Engineers and Riga Polytechnical Institute / RTU Alumni, Latvija, Rīga, 11.-12. oktobris, 2012. Riga: RTU Publishing House, 2012, 106.-106.lpp. ISBN 978-9934-10-357-5.

Publikācijas valoda
English (en)