The wide range of application of titania (TiO2) ceramics in many technological fields is related to its characteristics, such as high refractive index, good stability in aggressive environments, high hardness and biocompatibility. Bioactive materials form a bone-like apatite layer on their surfaces in the living body and bond to living bone trough apatite layer. Bioactivity of such a material can be enhanced tailoring surface morphology. The apatite forming ability on bioactive materials can be evaluated in simulated body fluid (SBF). This work aims at presenting the effects of particle size of raw material on the sintering process and formation of bone-like apatite on sintered ceramic in SBF. Reducing powder particle size to nanometer level (15 nm) green compact sintering begins at 450 °C. At the same conditions of thermal treatment smaller particle size of anatase powder leads to formation of smaller grain size of obtained TiO2 ceramic. Bioactivity of ceramic is enhanced using nanopowder as raw material.