Synthesis of 5-Substituted 3-Mercapto-1,2,4-Triazoles via Suzuki–Miyaura Reaction

Tetrahedron Letters 2013
Sarmīte Katkēviča, Pavlo Salun, Aigars Jirgensons

3-Bromo- and 3-iodo-N,S-dibenzyl-5-mercapto-1,2,4-triazoles were prepared and demonstrated as versatile building blocks for Suzuki–Miyaura cross-coupling with aryl, heteroaryl, and vinyl boronic acid derivatives. Deprotection of the resulting coupling products provided 5-substituted-3-mercapto-1,2,4-triazoles in good overall yields. This represents a novel and convenient approach for the introduction of a 3-mercapto-1,2,4-triazole substructure into target compounds.

Atslēgas vārdi
5-Mercapto-1,2,4-triazoles; Suzuki–Miyaura cross-coupling; Benzyl protection; Deprotection
DOI
10.1016/j.tetlet.2013.06.067
Hipersaite
http://www.sciencedirect.com/science/article/pii/S0040403913010344

Katkeviča, S., Salun, P., Jirgensons, A. Synthesis of 5-Substituted 3-Mercapto-1,2,4-Triazoles via Suzuki–Miyaura Reaction. Tetrahedron Letters, 2013, Vol.54, Iss.34, 4524.-4525.lpp. ISSN 0040-4039. Pieejams: doi:10.1016/j.tetlet.2013.06.067

Publikācijas valoda
English (en)