RTU Zinātniskās darbības rezultāti un resursi: Personāls

Informācija par autoru

Vārds, Uzvārds:

Aigars Jirgensons

Struktūrvienība:

(32300) Ķīmijas un ķīmijas tehnoloģijas institūts

Zinātniskais grāds:

Doktors

E-pasts:

Aigars.Jirgensons(at)rtu.lv

Publikācijas

Atrasti 144 rezultāti tiek attēloti no 1 līdz 10.

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library
(2024)

Jekaterina Boļšakova, Raitis Bobrovs, Larisa Varacheva, Anastasija Rudnickiha, Iveta Kaņepe, Emilio Parisini, Aigars Jirgensons
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Synthesis of 2-Arylquinazolines by Chan–Evans–Lam Coupling of 2-Formylphenylboronic Acids with Amidines
(2024)

Vitalii Solomin, Darija Zaharova, Aigars Jirgensons
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors
(2024)

Gints Kalniņš, Laura Ruduša, Anna L. Bula, Diāna Zeļencova-Gopejenko, Olga Bobiļeva, Mihails Sisovs, Kaspars Tārs, Aigars Jirgensons, Kristaps Jaudzems, Raitis Bobrovs
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Bioinspired Semisynthesis and Structure Revisions of Chlorinated Norsesquiterpenoids Rumphellatins A-C
(2024)

Georgijs Stakanovs, Anastasija Blazevica, Dace Rasiņa, Sergejs Beļakovs, Aigars Jirgensons
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome
(2024)

Chrislaine Withers-Martinez, Elīna Līdumniece, Fiona Hackett, Christine R Collins, Zahie Taha, Michael J Blackman, Aigars Jirgensons
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Repurposing Hsp90 Inhibitors as Antimicrobials Targeting Two-Component Systems Identifies Compounds Leading to Loss of Bacterial Membrane Integrity
(2024)

Blanca Fernandez-Ciruelos, Marco Albanese, anmol adhav, Vitalii Solomin, Arabela Ritchie-Martinez, Femke Taverne, Nadya Velikova, Aigars Jirgensons, Alberto Marina, Paul W Finn, Jerry M Wells
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Bridgehead Epoxide Iso-Euphoranin E from β-Caryophyllene Oxide via Sequential Cationic Formation and Scission of [4.3.2]Propellane
(2024)

Georgijs Stakanovs, Dace Rasiņa, Sergejs Beļakovs, Artis Kinēns, Aigars Jirgensons
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Substrate Analogues Entering the Lipoic Acid Salvage Pathway via Lipoate-Protein Ligase 2 Interfere with Staphylococcus aureus Virulence
(2024)

Albertina Scattolini, Konstantinos Grammatoglou, Anna Ņikitjuka, Aigars Jirgensons, Maria Cecilia Mansilla, Bjorn Windshugel
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Spiropyran-Based Photoisomerizable α-Amino Acid for Membrane-Active Peptide Modification
(2024)

Andrii Hrebonkin, Sergii Afonin, Anna Nikitjuka, Oleksandr V Borysov, Gundars Leitis, Oleg Babbi, Serhii Koniev, Theo Lorig, Stephan L Grage, Peter Nick, Anne S Ulrich, Aigars Jirgensons, Igor V Komarov
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Structure-Based Identification of Salicylic Acid Derivatives as Malarial Threonyl tRNA-Synthetase Inhibitors
(2024)

Raitis Bobrovs, Jekaterina Boļšakova, Jhon Alexander Rodriguez Buitrago, Larisa Varanceva, Marija Skvorcova, Iveta Kaņepe, Anastasija Rudnickiha, Emilio Parisini, Aigars Jirgensons
Zinātniskais raksts, kas indeksēts Web of science un/vai Scopus datu bāzē

Informācija par autoru

Publikācijas

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library
(2024)

Synthesis of 2-Arylquinazolines by Chan–Evans–Lam Coupling of 2-Formylphenylboronic Acids with Amidines
(2024)

Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors
(2024)

Bioinspired Semisynthesis and Structure Revisions of Chlorinated Norsesquiterpenoids Rumphellatins A-C
(2024)

Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome
(2024)

Repurposing Hsp90 Inhibitors as Antimicrobials Targeting Two-Component Systems Identifies Compounds Leading to Loss of Bacterial Membrane Integrity
(2024)

Bridgehead Epoxide Iso-Euphoranin E from β-Caryophyllene Oxide via Sequential Cationic Formation and Scission of [4.3.2]Propellane
(2024)

Substrate Analogues Entering the Lipoic Acid Salvage Pathway via Lipoate-Protein Ligase 2 Interfere with Staphylococcus aureus Virulence
(2024)

Spiropyran-Based Photoisomerizable α-Amino Acid for Membrane-Active Peptide Modification
(2024)

Structure-Based Identification of Salicylic Acid Derivatives as Malarial Threonyl tRNA-Synthetase Inhibitors
(2024)

Vadītie promocijas darbi

Eksotisku terpenoīdu sintēze no (–)-β-kariofilēna
(2024)

Development of Scalable Synthesis for Selected Serine Protease uPA Inhibitors
(2023)

Stannilmetilēteru un furāna atvasinājumu elektroķīmiska oksidēšana jaunu sintēzes metožu izveidei
(2023)

Development of Malarial Enzyme Inhibitors
(2023)

The Development of New Methods for the Synthesis of PLP-Dependent Enzyme Inhibitors and Exploring Covalent Inhibition Potential of Bacterial Enzyme O-Acetylserine Sulfhydrylase
(2023)

New Methods for the Synthesis and C–H Functionalization of Amino Alcohols
(2020)

Elektrofīlu inducētas ciklopropānu reakcijas ar nukleofīliem
(2018)

Malārijas aspartilproteināžu inhibitoru izveide
(2016)

Development of Malarial Protease PfSUB1 Inhibitors
(2014)

C-heteroatoms saites izveidošana luisa skābes katalizētās aliliskās aizvietošanas reakcijās
(2013)

Projekti

Atbalsts RTU doktora studiju īstenošanai - 2
Izglītība

Methods of critical infrastructure control
Enerģētika

Informācija par autoru

Publikācijas

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library (2024)

Synthesis of 2-Arylquinazolines by Chan–Evans–Lam Coupling of 2-Formylphenylboronic Acids with Amidines (2024)

Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors (2024)

Bioinspired Semisynthesis and Structure Revisions of Chlorinated Norsesquiterpenoids Rumphellatins A-C (2024)

Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome (2024)

Repurposing Hsp90 Inhibitors as Antimicrobials Targeting Two-Component Systems Identifies Compounds Leading to Loss of Bacterial Membrane Integrity (2024)

Bridgehead Epoxide Iso-Euphoranin E from β-Caryophyllene Oxide via Sequential Cationic Formation and Scission of [4.3.2]Propellane (2024)

Substrate Analogues Entering the Lipoic Acid Salvage Pathway via Lipoate-Protein Ligase 2 Interfere with Staphylococcus aureus Virulence (2024)

Spiropyran-Based Photoisomerizable α-Amino Acid for Membrane-Active Peptide Modification (2024)

Structure-Based Identification of Salicylic Acid Derivatives as Malarial Threonyl tRNA-Synthetase Inhibitors (2024)

Vadītie promocijas darbi

Eksotisku terpenoīdu sintēze no (–)-β-kariofilēna (2024)

Development of Scalable Synthesis for Selected Serine Protease uPA Inhibitors (2023)

Stannilmetilēteru un furāna atvasinājumu elektroķīmiska oksidēšana jaunu sintēzes metožu izveidei (2023)

Development of Malarial Enzyme Inhibitors (2023)

The Development of New Methods for the Synthesis of PLP-Dependent Enzyme Inhibitors and Exploring Covalent Inhibition Potential of Bacterial Enzyme O-Acetylserine Sulfhydrylase (2023)

New Methods for the Synthesis and C–H Functionalization of Amino Alcohols (2020)

Elektrofīlu inducētas ciklopropānu reakcijas ar nukleofīliem (2018)

Malārijas aspartilproteināžu inhibitoru izveide (2016)

Development of Malarial Protease PfSUB1 Inhibitors (2014)

C-heteroatoms saites izveidošana luisa skābes katalizētās aliliskās aizvietošanas reakcijās (2013)

Projekti

Atbalsts RTU doktora studiju īstenošanai - 2 Izglītība

Methods of critical infrastructure control Enerģētika

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library
(2024)

Synthesis of 2-Arylquinazolines by Chan–Evans–Lam Coupling of 2-Formylphenylboronic Acids with Amidines
(2024)

Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors
(2024)

Bioinspired Semisynthesis and Structure Revisions of Chlorinated Norsesquiterpenoids Rumphellatins A-C
(2024)

Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome
(2024)

Repurposing Hsp90 Inhibitors as Antimicrobials Targeting Two-Component Systems Identifies Compounds Leading to Loss of Bacterial Membrane Integrity
(2024)

Bridgehead Epoxide Iso-Euphoranin E from β-Caryophyllene Oxide via Sequential Cationic Formation and Scission of [4.3.2]Propellane
(2024)

Substrate Analogues Entering the Lipoic Acid Salvage Pathway via Lipoate-Protein Ligase 2 Interfere with Staphylococcus aureus Virulence
(2024)

Spiropyran-Based Photoisomerizable α-Amino Acid for Membrane-Active Peptide Modification
(2024)

Structure-Based Identification of Salicylic Acid Derivatives as Malarial Threonyl tRNA-Synthetase Inhibitors
(2024)

Eksotisku terpenoīdu sintēze no (–)-β-kariofilēna
(2024)

Development of Scalable Synthesis for Selected Serine Protease uPA Inhibitors
(2023)

Stannilmetilēteru un furāna atvasinājumu elektroķīmiska oksidēšana jaunu sintēzes metožu izveidei
(2023)

Development of Malarial Enzyme Inhibitors
(2023)

The Development of New Methods for the Synthesis of PLP-Dependent Enzyme Inhibitors and Exploring Covalent Inhibition Potential of Bacterial Enzyme O-Acetylserine Sulfhydrylase
(2023)

New Methods for the Synthesis and C–H Functionalization of Amino Alcohols
(2020)

Elektrofīlu inducētas ciklopropānu reakcijas ar nukleofīliem
(2018)

Malārijas aspartilproteināžu inhibitoru izveide
(2016)

Development of Malarial Protease PfSUB1 Inhibitors
(2014)

C-heteroatoms saites izveidošana luisa skābes katalizētās aliliskās aizvietošanas reakcijās
(2013)

Atbalsts RTU doktora studiju īstenošanai - 2
Izglītība

Methods of critical infrastructure control
Enerģētika