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Publikācija: Calcium Phosphate Bone Cements Reinforced with Biodegradable Polymer Fibres for Drug Delivery

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Publikācijas valoda English (en)
Nosaukums oriģinālvalodā Calcium Phosphate Bone Cements Reinforced with Biodegradable Polymer Fibres for Drug Delivery
Pētniecības nozare 2. Inženierzinātnes un tehnoloģijas
Pētniecības apakšnozare 2.5. Materiālzinātne
Autori Zilgma Irbe
Dagnija Loča
Ivita Bistrova
Līga Bērziņa-Cimdiņa
Atslēgas vārdi
Anotācija It is well known that calcium phosphate bone cements set at low temperatures, therefore a wide range of drugs can be introduced within these cements. Calcium phosphate bone cements are generally regarded as having low mechanical strength that can be further lowered, if large amounts of drugs are incorporated. In this case additional porosity will occur and cause mechanical instability of bone cements. Thus in the current research calcium phosphate bone cements were reinforced with poly lactic-co-glycolic acid or silk microfibers and composite application towards the local vancomycin (an antibiotic) delivery was evaluated. Results show that by reinforcing a-tricalcium phosphate bone cements with biodegradable silk and poly lactic-co-glycolic acid fibres it was possible to increase cement compressive strength from 10 MPa up to 20 MPa. The burst release of vancomycin from the prepared cements was observed in the first 24 h, but afterwards vancomycin was gradually released in a linear way for more than 25 days.
DOI: 10.4028/www.scientific.net/KEM.604.184
Hipersaite: http://www.scientific.net/KEM.604.184 
Atsauce Irbe, Z., Loča, D., Bistrova, I., Bērziņa-Cimdiņa, L. Calcium Phosphate Bone Cements Reinforced with Biodegradable Polymer Fibres for Drug Delivery. Key Engineering Materials, 2014, Vol.604, 184.-187.lpp. ISSN 1662-9795. Pieejams: doi:10.4028/www.scientific.net/KEM.604.184
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