Within current research calcium phosphates were synthesized by wet chemical precipitation method in laboratory and pilot scale reactor. The aim of this work was to study the influence of main technological parameters of wet chemical precipitation synthesis and scale-up of laboratory synthesis. The results show that it is possible to obtain calcium phosphates with different and reproducible phase compositions such as hydroxyapatite, β-tricalcium phosphate and biphasic calcium phosphates in pilot scale reactor. Using the developed method it was possible to increase the product yield more than 30 times compared to laboratory scale method.