The main inorganic component of bone is calcium phosphate (CaP) salts. Thereby synthetic CaPs, such as hydroxyapatite (HAp), β-tricalcium phosphate (β-TCP) due to their unique properties – biocompatibility, bioactivity and/or biodegradability, and osteoconductivity, are considered to be promising bone replacement materials. CaPs present themselves as prime materials for modifications and functionalizations, aiming for improvements on physicochemical and biological aspects of novel graft materials. Nowadays interest is turning towards modified synthetic CaPs involving the substitution of various ions, which possess antibacterial properties and are able to act on bone diseases. The incorporation of such ions have influence on the physical, chemical, and physiological properties of the CaPs products and consequently on the mineralization, demineralization, and remineralization of the calcified tissues. Thus, the main goal of our work is to synthesize with divalent cations (i.e., Mg, Sr and Zn) substituted CaPs through modified wet chemical precipitation method, and to evaluate the effect of the incorporated ions on the synthesis products in bulk and particle level.