Local Recovery of Bone Tissue in Osteoporotic Rabbit Hip after Implantation of HAP/TCP Bioceramic Granules

27th European Conference on Biomaterials: Final Programme and Book of Abstracts 2015
Ilze Šalma, Sandris Petronis, Māra Pilmane, Andrejs Skaģers, Vita Šteinberga, Jānis Ločs

Biphasic calcium phosphate (BCP) as bone grafting substitute can be used for reinforcement of osteoporotic bone and for promotion of bone healing and bone defect filling1. Experimental and clinical data showed bioactivity of BCP2,3. In current study the BCP ceramic granules with HAp/b-TCP ratio of 90/10 was selected as appropriate. It is supposed that the minor amount of b-TCP in the composition due to relatively faster resorbtion rate compared to HAp will ensure the initial burst of releasing calcium and orthophosphate ions into the biological medium, thus seeding new bone formation. The majority of HAp remaining after resorbtion of b-TCP will act as a tissue scaffold for the complete formation of new bone. Objective of our study was to evaluate by immunohistochemical method local bone tissue response to BCP ceramic granules implanted in experimental animals. Investigation of osteocalcin (OC) and osteopontin (OP) expression helps to understand bone tissue regeneration potential and remodeling after BCP implantation.

Atslēgas vārdi
Biphasic calcium phosphate, bone grafting, Bioceramic Granules

Šalma, I., Petronis, S., pilmane, M., Skaģers, A., Zālīte, V., Ločs, J. Local Recovery of Bone Tissue in Osteoporotic Rabbit Hip after Implantation of HAP/TCP Bioceramic Granules. No: 27th European Conference on Biomaterials: Final Programme and Book of Abstracts, Polija, Krakow, 30. Aug-3. Sep., 2015. Krakow: Scientific Publishing House „Akapit”, 2015, 409.-409.lpp. ISBN 978-83-63663-63-6.

Publikācijas valoda
English (en)