Pepsinogen Testing for Evaluation of the Success of Helicobacter Pylori Eradication at 4 Weeks after Completion of Therapy
Medicina 2014
Mārcis Leja, Sanita Lapina, Inese Poļaka, Dace Rudzīte, Ilona Vilkoite, Ilva Daugule, A Belkovets, S Pimanov, J Makarenko, I Tolmanis, A Lejnieks, V Boka, I Rumba-Rozenfelde, U Vikmanis

Background and objective: Pepsinogen levels in plasma are increased by inflammation in the gastric mucosa, including inflammation resulting from Helicobacter pylori infection. A decrease in pepsinogen II level has been suggested as a reliable marker to confirm the successful eradication of infection. The aim of our study was to evaluate the potential role of pepsinogens I and II, gastrin-17 and H. pylori antibodies in confirming successful eradication. Material and methods: Altogether 42 patients (25 women, 17 men), mean age 45 years (range 23-74), were enrolled. Pepsinogens I and II, gastrin-17 and H. pylori IgG antibodies were measured in plasma samples using an ELISA test (Biohit, Oyj., Finland) before the eradication and 4 weeks after completing the treatment. The success of eradication was determined by a urea breath test. Results: Eradication was successful in 31 patients (74%) and unsuccessful in 11 patients (26%). Pepsinogen II decreased significantly in both the successful (P = 0.029) and unsuccessful (P = 0.042) eradication groups. Pepsinogen I decreased significantly in the successful (P = 0.025) but not the unsuccessful (P = 0.29) eradication group. The pepsinogen I/II ratio increased in the successful eradication group (P = 0.0018) but not in the group in which treatment failed (P = 0.12). There were no differences in gastrin-17 or H. pylori antibody values. Conclusions: A decrease in pepsinogen II levels cannot be used as a reliable marker for the successful eradication of H. pylori 4 weeks after the completion of treatment. The increase in pepsinogen I/II ratio reflects differences in pepsinogen production following the eradication irrespective of improvement in atrophy. © 2014 Lithuanian University of Health Sciences. Production and hosting by Elsevier Urban & Partner Sp. z o.o.


Atslēgas vārdi
gastric cancer, diagnostics, screening
DOI
10.1016/j.medici.2014.05.001
Hipersaite
http://www.sciencedirect.com/science/article/pii/S1010660X14000020

Leja, M., Lapina, S., Poļaka, I., Rudzīte, D., Vilkoite, I., Daugule, I., Belkovets, A., Pimanov, S., Makarenko, J., Tolmanis, I., Lejnieks, A., Boka, V., Rumba-Rozenfelde, I., Vikmanis, U. Pepsinogen Testing for Evaluation of the Success of Helicobacter Pylori Eradication at 4 Weeks after Completion of Therapy. Medicina, 2014, Vol.50, Iss.1, 8.-13.lpp. ISSN 1010-660X. Pieejams: doi:10.1016/j.medici.2014.05.001

Publikācijas valoda
English (en)
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