Indium-Triflate-Catalyzed Ritter Reaction in Liquid Sulfur Dioxide

European Journal or Organic Chemistry 2016
Daniels Posevins, Krista Gulbe, Māris Turks

The use of liquid sulfur dioxide as a reaction solvent facilitates the Ritter reaction between alcohols and nitriles. In(OTf )3 was found to be a viable catalyst for this transformation. The newly developed catalytic conditions for the Ritter reaction were successfully applied to the synthesis of various amides, which were formed in good to excellent yields. The catalytic activation of secondary alcohols for Ritter reactions in liquid sulfur dioxide was also found to be effective.

Atslēgas vārdi
Synthetic methods, Sulfur dioxide, Solvent effects, Carbocations, Amides, Cyanides
DOI
10.1002/ejoc.201600013
Hipersaite
http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201600013/abstract

Posevins, D., Suta, K., Turks, M. Indium-Triflate-Catalyzed Ritter Reaction in Liquid Sulfur Dioxide. European Journal or Organic Chemistry, 2016, Vol.2016, Iss.7, 1414.-1419.lpp. e-ISSN 1099-0690. Pieejams: doi:10.1002/ejoc.201600013

Publikācijas valoda
English (en)