Antibacterial Efficiency of Hydroxyapatite Biomaterials with Biodegradable Polylactic Acid and Polycaprolactone Polymers Saturated with Antibiotics
Proceedings of the Latvian Academy of Sciences. Section B: Natural, Exact, and Applied Sciences 2016
Juta Kroiča, Ingus Skadiņš, Ilze Šalma, Aigars Reinis, Marina Putniņa, Dagnija Rostoka, Natalija Berza

Infections continue to spread in all fields of medicine, and especially in the field of implant biomaterial surgery, and not only during the surgery, but also after surgery. Reducing the adhesion of bacteria could decrease the possibility of biomaterial-associated infections. Bacterial adhesion could be reduced by local antibiotic release from the biomaterial. In this in vitro study, hydroxyapatite biomaterials with antibiotics and biodegradable polymers were tested for their ability to reduce bacteria adhesion and biofilm development. This study examined the antibacterial efficiency of hydroxyapatite biomaterials with antibiotics and biodegradable polymers against Staphylococcus epidermidis and Pseudomonas aeruginosa. The study found that hydroxyapatite biomaterials with antibiotics and biodegradable polymers show longer antibacterial properties than hydroxyapatite biomaterials with antibiotics against both bacterial cultures. Therefore, the results of this study demonstrated that biomaterials that are coated with biodegradable polymers release antibiotics from biomaterial samples for a longer period of time and may be useful for reducing bacterial adhesion on orthopedic implants.


Atslēgas vārdi
antimicrobial agents; biodegradable polymers.; composite materials; P. aeruginosa; S. epidermidis
DOI
10.1515/prolas-2016-0035
Hipersaite
http://www.degruyter.com/view/j/prolas.2016.70.issue-4/prolas-2016-0035/prolas-2016-0035.xml

Kroiča, J., Skadiņš, I., Šalma, I., Reinis, A., Sokolova, M., Rostoka, D., Berza, N. Antibacterial Efficiency of Hydroxyapatite Biomaterials with Biodegradable Polylactic Acid and Polycaprolactone Polymers Saturated with Antibiotics. No: Proceedings of the Latvian Academy of Sciences. Section B: Natural, Exact, and Applied Sciences, Latvija, Rīga, 14.-15. decembris, 2015. Latvia: Latvian Academy of Sciences, 2016, 220.-226.lpp. ISSN 1407-009X. Pieejams: doi:10.1515/prolas-2016-0035

Publikācijas valoda
English (en)
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