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Publikācija: Antibacterial Efficiency of Hydroxyapatite Biomaterials with Biodegradable Polylactic Acid and Polycaprolactone Polymers Saturated with Antibiotics

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Nosaukums oriģinālvalodā Antibacterial Efficiency of Hydroxyapatite Biomaterials with Biodegradable Polylactic Acid and Polycaprolactone Polymers Saturated with Antibiotics
Pētniecības nozare 2. Inženierzinātnes un tehnoloģijas
Pētniecības apakšnozare 2.5. Materiālzinātne
Autori Juta Kroiča
Ingus Skadiņš
Ilze Šalma
Aigars Reinis
Marina Putniņa
Dagnija Rostoka
Natalija Berza
Atslēgas vārdi antimicrobial agents; biodegradable polymers.; composite materials; P. aeruginosa; S. epidermidis
Anotācija Infections continue to spread in all fields of medicine, and especially in the field of implant biomaterial surgery, and not only during the surgery, but also after surgery. Reducing the adhesion of bacteria could decrease the possibility of biomaterial-associated infections. Bacterial adhesion could be reduced by local antibiotic release from the biomaterial. In this in vitro study, hydroxyapatite biomaterials with antibiotics and biodegradable polymers were tested for their ability to reduce bacteria adhesion and biofilm development. This study examined the antibacterial efficiency of hydroxyapatite biomaterials with antibiotics and biodegradable polymers against Staphylococcus epidermidis and Pseudomonas aeruginosa. The study found that hydroxyapatite biomaterials with antibiotics and biodegradable polymers show longer antibacterial properties than hydroxyapatite biomaterials with antibiotics against both bacterial cultures. Therefore, the results of this study demonstrated that biomaterials that are coated with biodegradable polymers release antibiotics from biomaterial samples for a longer period of time and may be useful for reducing bacterial adhesion on orthopedic implants.
DOI: 10.1515/prolas-2016-0035
Hipersaite: http://www.degruyter.com/view/j/prolas.2016.70.issue-4/prolas-2016-0035/prolas-2016-0035.xml 
Atsauce Kroiča, J., Skadiņš, I., Šalma, I., Reinis, A., Sokolova, M., Rostoka, D., Berza, N. Antibacterial Efficiency of Hydroxyapatite Biomaterials with Biodegradable Polylactic Acid and Polycaprolactone Polymers Saturated with Antibiotics. No: Proceedings of the Latvian Academy of Sciences. Section B: Natural, Exact, and Applied Sciences, Latvija, Rīga, 14.-15. decembris, 2015. Latvia: Latvian Academy of Sciences, 2016, 220.-226.lpp. ISSN 1407-009X. Pieejams: doi:10.1515/prolas-2016-0035
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ID 22595