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Publikācija: Crystal Structure of Plasmodium Falciparum Proplasmepsin IV: The Plasticity of Proplasmepsins

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Publikācijas valoda English (en)
Nosaukums oriģinālvalodā Crystal Structure of Plasmodium Falciparum Proplasmepsin IV: The Plasticity of Proplasmepsins
Pētniecības nozare 1. Dabaszinātnes
Pētniecības apakšnozare 1.4. Ķīmija
Autori R. Recacha
Kristaps Jaudzems
I. Akopjana
Aigars Jirgensons
K. Tars
Atslēgas vārdi aspartic protease zymogen | malaria | Plasmodium falciparum | proplasmepsin IV
Anotācija Plasmepsin IV from Plasmodium falciparum (PM IV) is a promising target for the development of novel antimalarial drugs. Here, the crystal structure of the truncated zymogen of PM IV (pPM IV), consisting of the mature enzyme plus a prosegment of 47 residues, has been determined at 1.5 Å resolution. pPM IV presents the fold previously described for studied proplasmepsins, displaying closer similarities to proplasmepin IV from P. vivax (pPvPM) than to the other two proplasmepsins from P. falciparum. The study and comparison of the pPM IV structure with the proplasmepsin structures described previously provide information about the similarities and differences in the inactivation-activation mechanisms among the plasmepsin zymogens.
DOI: 10.1107/S2053230X16011663
Hipersaite: http://scripts.iucr.org/cgi-bin/paper?S2053230X16011663 
Atsauce Recacha, R., Jaudzems, K., Akopjana, I., Jirgensons, A., Tars, K. Crystal Structure of Plasmodium Falciparum Proplasmepsin IV: The Plasticity of Proplasmepsins. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2016, Vol.72, 659.-666.lpp. ISSN 2053-230X. Pieejams: doi:10.1107/S2053230X16011663
Papildinformācija Citējamību skaits:
ID 23185