Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are responsible for cleavage of extracellular matrix proteins. Because of their effect on both physiological and pathological processes, MMPs have become interesting targets for treatment of cancer. In addition, it is known that MMP-2 has the most important impact to tumor growth. Based on previous research, new series of aziridine and azetidine derivatives containing 1,4-disubstituted 1,2,3-triazole in the side chain as well as aziridine derivatives containing 1,5-disubstituted 1,2,3-triazole in the side chain were synthesized using transition metals catalyzed Huisgen 1,3-dipolar cycloaddition. MMP-2 inhibition studies of target compounds revealed some promising results among aziridine derivatives containing 1,4-disubstituted 1,2,3-triazole, while for other two series inhibition potency was not detected.