Search for New MMP-2 Inhibitors among Small Nitrogen Heterocycles Containing Disubstituted 1,2,3-Triazole in the Side Chain

Abstracts of the Riga Technical University 56th International Scientific Conference : Section: Materials Science and Applied Chemistry 2015
Krista Gulbe, Diāna Stamberga, Andrejs Solops, Ilona Domracheva, Irina Shestakova, Māris Turks

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are responsible for cleavage of extracellular matrix proteins such as collagen, gelatin, elastin and casein. Because of their effect on both physiological and pathological processes, MMPs have become interesting targets for treatment of cancer. In addition, it is known that MMP-2 has the most important impact to tumour growth. Previously, our research group has identified aziridine derivatives with 1,4-disubstituted 1,2,3-triazole in the side chain as a new class of MMP-2 inhibitors.2,3 Herein we report futher investigation of these aziridine derivatives as well as new research among aziridines containing 1,5-disubstituted 1,2,3-triazole and azetidines containing 1,4-disubstituted 1,2,3-triazole in the side chain.

Atslēgas vārdi
aziridine-triazole conjugates, azetidine-triazole conjugates, azide-alkyne cycloaddtition, MMP-2 inhibitors

Suta, K., Stamberga, D., Solops, A., Domracheva, I., Shestakova, I., Turks, M. Search for New MMP-2 Inhibitors among Small Nitrogen Heterocycles Containing Disubstituted 1,2,3-Triazole in the Side Chain. No: Abstracts of the Riga Technical University 56th International Scientific Conference : Section: Materials Science and Applied Chemistry, Latvija, Riga, 14.-16. oktobris, 2015. Riga: RTU Press, 2015, 9.-9.lpp. ISBN 978-9934-10-733-7.

Publikācijas valoda
English (en)