Amide Group Directed Protonolysis of Cyclopropane. An Approach to 2,2-Disubstituted Pyrrolidines
17th Blue Danube Symposium on Heterocyclic Chemistry: Abstract Book
2017
Marija Skvorcova,
Aigars Jirgensons
We have shown that the regioselective protonolytic C −C bond cleavage of acylated
aminomethyl cyclopropanes 1 can be achieved using trifluoroacetic acid. The intermediate
tertiary carbenium ion 2 undergoes intramolecular amination to give 2,2 -disubstituted
pyrrolidines 3 in very good yields (more than 10 examples, yield up to 99 %)
Atslēgas vārdi
pyrrolidine, protonolysis, protonated amide
Skvorcova, M., Jirgensons, A. Amide Group Directed Protonolysis of Cyclopropane. An Approach to 2,2-Disubstituted Pyrrolidines. No: 17th Blue Danube Symposium on Heterocyclic Chemistry: Abstract Book, Austrija, Linz, 30. Aug-2. Sep., 2017. Linz: Johannes Kepler University, 2017, 118.-118.lpp.
Publikācijas valoda
English (en)