Easy Access to Isomeric 7-Deazapurine–1,2,3-Triazole Conjugates via SNAr and CuAAC Reactions of 2,6-Diazido-7-deazapurines

Synlett 2018
Jonas Bucevicius, Māris Turks, Sigitas Tumkevecius

A simple and efficient synthesis of isomeric 7-deazapurine–1,2,3-triazole conjugates with amino substituents from readily available 9-alkyl-2,6-diazido-7-deazapurines has been developed using consecutive CuAAC and regioselective nucleophilic substitution reactions of ­azido and 1,2,3-triazole groups with amines.

Atslēgas vārdi
heterocycles - 7-deazapurines - triazoles - click chemistry - nucleophilic aromatic substitution - regioselectivity
DOI
10.1055/s-0036-1590942
Hipersaite
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1590942

Bucevicius, J., Turks, M., Tumkevecius, S. Easy Access to Isomeric 7-Deazapurine–1,2,3-Triazole Conjugates via SNAr and CuAAC Reactions of 2,6-Diazido-7-deazapurines. Synlett, 2018, Vol. 29, No. 4, 525.-529.lpp. ISSN 0936-5214. e-ISSN 1437-2096. Pieejams: doi:10.1055/s-0036-1590942

Publikācijas valoda
English (en)