Zinātniskās darbības atbalsta sistēma
Latviešu English

Publikācija: 2

Publikācijas veids Raksts konferenču tēžu krājumā
Pamatdarbībai piesaistītais finansējums Pētniecības projekti
Aizstāvēšana: ,
Publikācijas valoda English (en)
Nosaukums oriģinālvalodā 2,6-Diazidopurine Derivatives as Substrates in Reactions with Arylthiols
Pētniecības nozare 1. Dabaszinātnes
Pētniecības apakšnozare 1.4. Ķīmija
Pētniecības platforma Materiāli, procesi un tehnoloģijas
Autori Andris Jeminejs
Ērika Bizdēna
Irina Novosjolova
Atslēgas vārdi Purine derivatives, thiopurine, thiphenols, nucleophilic substitution
Anotācija Purine and thiopurine derivatives are widely studied due to their broad spectrum of biological activity. Some of them have already been used as an effective tool in the treatment of cancer and autoimmune disorders. 2,6-Diazidopurine substrate has been proven to be a valuable starting material in the synthesis of new arylthiopurine derivatives. Nucleophilic substitution with thiophenols can be mainly observed at C2 position of purine, providing 2-arylthio-6-azidopurine derivatives with good yields. In solution these compounds exist in azide-tetrazole equilibrium which is dependent on several factors, such as temperature, solvent polarity and substituent electron donating properties. Further CuAAC reaction and different sequence of the reactions leaded to 2-arylthio-6 triazolyl- and 6-arylthio-2-triazolylpurine derivatives. Despite the location of triazolyl- and thiogroups following nucleophilic substitution with piperidine was observed regioselectively at C6 position of purine.
Atsauce Jeminejs, A., Bizdēna, Ē., Novosjolova, I. 2,6-Diazidopurine Derivatives as Substrates in Reactions with Arylthiols. No: Materials Science and Applied Chemistry 2019: Programme and Abstract Book, Latvija, Rīga, 24.-24. oktobris, 2019. Rīga: 2019, 43.-43.lpp.
Pilnais teksts Pilnais teksts
ID 29803