Synthesis and Cytotoxicity of Hybrids of 1,3,4- or 1,2,5-Oxadiazoles Tethered from Ursane and Lupane Core with 1,2,3-Triazole
Steroids 2020
S.A. Popov, M.D. Semenova, D.S. Baev, T.S. Frolova, M.A. Shestopalov, C. Wang, Z. Qi, E.E. Shults, Māris Turks

Ursane and lupane type (1-((5-aryl-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl and (1-((4-methyl-2-oxido-1,2,5-oxadiazol-3-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl hybrids were prepared by 1,3-cycloaddition reactions of azole-derived azides with alkyne esters connected to positions C-3 and C-28 of triterpene core and tested for cytotoxicity. Hybrid compounds of 1,3,4-oxadiazoles attached at positions 3- and 28- of triterpenoid frame via triazole spacer and combinations of 1,2,5-oxadiazole or 1,3,4-oxadiazole, tethered with succinate linker and 1,2,3-triazole at the position 3- of the ursane backbone, were inactive in relation to all the cancer cells tested. Eventually, combinations of furoxan fragment and 1,2,3-triazole linked to C-28 position of triterpene backbone demonstrated marked cytotoxic activity towards MCF-7 and HepG2 cells. The most active ester of ursolic acid with (1-((4-methyl-2-oxido-1,2,5-oxadiazol-3-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl substituent and 3-O-acetyl group was superior in activity and selectivity over doxorubicin and ursolic acid on MCF-7 cells. The length of the carbon spacer group may be of crucial importance for cytotoxicity. The introduction of the additional ester linker between the C-28 of triterpenoid and triazole or changing triazole spacer between furoxan moiety and triterpenoid core resulted in activity decrease against all the tested cells. In accordance with molecular modeling results, the activity of new derivatives may be explained in terms of the interaction of the new hybrid molecules and Mdm2 binding sites.


Atslēgas vārdi
1,3-cycloaddition,Triterpenoid conjugate, 1,2,3-triazole, 1,3,4- 1,2,5-oxadiazole, Cytotoxicity tests, MDM-2-docking
DOI
10.1016/j.steroids.2020.108698
Hipersaite
https://www.sciencedirect.com/science/article/abs/pii/S0039128X20301240

Popov, S., Semenova, M., Baev, D., Frolova, T., Shestopalov, M., Wang, C., Qi, Z., Shults, E., Turks, M. Synthesis and Cytotoxicity of Hybrids of 1,3,4- or 1,2,5-Oxadiazoles Tethered from Ursane and Lupane Core with 1,2,3-Triazole. Steroids, 2020, Vol. 162, Article number 108698. ISSN 0039-128X. e-ISSN 1878-5867. Pieejams: doi:10.1016/j.steroids.2020.108698

Publikācijas valoda
English (en)
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