Laser-induced periodic surface structures (LIPSS) can be formed on different materials such as metals, semiconductors, and dielectrics. Our preliminary study has shown that it is possible to obtain surfaces with wettability angle anisotropy by the formation of LIPSS on the steel. The aim of the study is to develop laser technology to form the metal surface with controlled anisotropic tribological properties. To achieve this aim, the surface of cylindrical shape steel samples were irradiated by Nd:YAG laser in order to obtain LIPSS perpendicular and parallel to motion direction. The samples were treated with following irradiating parameters: λ=1064 nm, W= 41 mJ, τ=6 ns, hatch spacing - 0.4 mm; rotating speed 1 mm/s. The experiments confirmed that morphological changes induced on the steel surface by laser radiation (perpendicularly LIPSS samples) leads to decreased moment of friction by more than 10% in comparison with non-irradiated. During the tribotest time the difference in friction moment between parallely and perpendicularly irradiated samples was about 12% in the first part of test and drop to about 5% from half time of run.