α-tricalcium phosphate (α-TCP) is a bioactive, biocompatible and osteoconductive material that reacts rapidly and hardens in the presence of aqueous salt solutions to form calcium phosphate bone cement (CPC). During this reaction, α-TCP transitions into a calcium-deficient hydroxyapatite (CDHA) phase with chemical composition and morphology similar to that of a natural bone mineral. Cement based on α-TCP is widely used to treat bone defects and regenerate damaged bone tissue [1], [2]. Within the current research, the impact of low-temperature synthesised α-TCP powder properties like particle size, specific surface area and density on the resulting CPC was evaluated in terms of setting time and porosity. CPC setting reaction kinetics and pH change in deionised water and simulated body fluid (SBF) of CPC samples depending on time was studied and evaluated.