Commercially available fibrin glues take advantage of a simplified method for fibrinogen activation, bypassing the clotting cascade. Platelet-rich fibrin (PRF) is an autologous material derived from a patient blood with a high concentration of platelets and leukocytes. It contains high concentrations of growth factors and biologically active substances that play an important role in providing hemostasis and bone healing. PRF is used in different fields of medicine, including dentistry, oral and maxillofacial surgery. Therefore, the aim of this study was to obtain and to compare commercial fibrin (K-fibrin) and autologous fibrin (A-fibrin) matrices.