Cyber-Physical Systems (CPS) are interconnected real-time systems that combine discrete computation with continuous physical processes in a controllable way. CPS systems are essential to form resilient Critical Infrastructures (CI), which significantly impact the quality of life, as they are assets (such as facilities, systems, sites and networks) necessary for delivering the important services upon which daily life depends. The ever-increasing use of CPS extends the risk of attacks, which conceptually can become threat for the CI. Preparedness and protection of CPS are important but not enough to keep them secure. Further analysis of CPS is required to design robust and secure systems. CPS need to be resilient in known and unknown threats, which can harm the CPS itself, the relevant infrastructures and most importantly, every vital societal function. Over the years, many methodologies have been developed for safely and securely control and monitoring CPS. This e-book does not only provide the theoretical background as literature review, but also offers essential procedures for modelling realistic systems. The near to reality synthetic models are applied on respective simulation packages and platforms for harvesting accurate data for analysing the CPS. The information from these sets of data is therefore deployed for monitoring the CPS as part of CI at control centres.