CuO on mesoporous silica catalyst was prepared with post synthesis impregnation method, and the effects of Al and Co promoters on CuO/SBA-15/kaolinite catalyst properties and CO2 hydrogenation were studied. The mixing technology with kaolinite clay (containing Al2O3) was used to obtain the granules and to enhance the CO2 conversion to methanol as a product. The performance of all catalysts for catalytic hydrogenation of CO2 was evaluated on a fixed-bed tubular micro-activity reactor at 20 bar and 250°C with H2/CO2 molar ratio 3:1. XRD analysis, N2 adsorption-desorption analysis and SEM-EDX analysis indicated that the mesoporous structure of SBA-15 remains after loading with CuO and promoters, and after mixing with kaolinite clay. Results were compared with results obtained with commercial CuO/Al2O3 catalyst, which showed high MeOH selectivity (78%) during CO2 hydrogenation reaction.