The reduction of construction costs as needed to increase construction productivity forces to the introduction of alternative construction solutions. Thus, the share of structural insulated panels for single-family houses is increasing. Despite the fact it is a widely used technology in the USA, there is a significant information gap for safe application in Baltic climatic conditions. The dynamic hygrothermal simulations DELPHIN was used to evaluate risks of mold growth and interstitial condensation. The city of Riga was selected to evaluate the hydrothermal performance of SIP panels. The different indoor air parameters were considered for in-depth evaluation. It was found that there is no harmful interstitial condensation and mold risk stayed at a relatively low level. However, wall orientation plays a significant role in whole year moisture accumulation dynamic.