The concept of openness is broad, and in this article, the aim is to discover the main conditions that promote teaching staff's openness to new experiences in the study process in this era when traditional educational practices are changing, and digitization processes are prevailing. Recognizing these conditions is essential for universities because the teaching staff is of great importance in how the study processes occur and the feedback link with students. The authors conducted the research as a systematic literature review using qualitative content analysis to interpret the literature and answer the research question, "What conditions promote teaching staff openness to new experiences in the study process?" Based on the application of a literature review and qualitative content analysis, the authors have obtained results that include several conditions with specific frequencies, answering the research question. The main conditions are internationalization, digital competence, and the personality traits of the teaching staff.