Total Synthesis and Determination of the Absolute Configuration of (−)-Dolabriferol

Angewandte Chemie International Edition 2010
Sylvain Laclef, Māris Turks, Pierre Vogel

A reaction cascade combining sulfur dioxide with a 1-oxy-1,3-diene and (E)-silyl enol ether formed the basis of a short total synthesis of (−)-dolabriferol. The absolute configuration of this natural product, which was first extracted from a gastropod mollusc in 1996, was established unequivocally.

Atslēgas vārdi
asymmetric synthesis;natural products;polypropionates;SO2 umpolung;stereotriads
DOI
10.1002/anie.201003735
Hipersaite
http://onlinelibrary.wiley.com/doi/10.1002/anie.201003735/abstract

Laclef, S., Turks, M., Vogel, P. Total Synthesis and Determination of the Absolute Configuration of (−)-Dolabriferol. Angewandte Chemie International Edition, 2010, Vol.49, Iss.45, 8525.-8527.lpp. e-ISSN 1521-3773. Pieejams: doi:10.1002/anie.201003735

Publikācijas valoda
English (en)