The Synthesis and X-ray Studies of 6-pyrrolidinyl-2-triazolyl Purine Arabinonucleoside

2013
Irina Novosjolova, Ērika Bizdēna, Sergejs Beļakovs, Māris Turks

C(6)-Pyrrolidinyl derivative with triazolyl moiety at C(2)-position was obtained from 2,6-bis-triazolylpurine arabinonucleoside via C(6)-regioselective nucleophilic substituon of 1,2,3-triazolyl moiety with pyrrolidine. The obtained compound was studied by NMR, X-ray, UV/VIS and emission spectra. Pyranose form of arabinose residue and α-configuration of the obtained compound were unambiguously proven by NMR and X-ray studies.

Atslēgas vārdi
purine arabinonucleosides, 2,6-bis-triazolyl purines, 1,3-dipolar cycloaddition, heteroaromatic nucleophilic substitution, X-ray
DOI
10.7250/msac.2013.007

Novosjolova, I., Bizdēna, Ē., Beļakovs, S., Turks, M. The Synthesis and X-ray Studies of 6-pyrrolidinyl-2-triazolyl Purine Arabinonucleoside. Materiālzinātne un lietišķā ķīmija . Nr.28, 2013, 39.-44.lpp. ISSN 1407-7353. e-ISSN 2255-8713. Pieejams: doi:10.7250/msac.2013.007

Publikācijas valoda
English (en)