Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1
Chemistry of Heterocyclic Compounds
2015
Samir Satish Kher,
M. Penzo,
S. Fulle,
J. P. Ebejer,
P. W. Finn,
M. J. Blackman,
Aigars Jirgensons
2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds. The synthesis of analog series and investigation of their inhibitory activity provided preliminary structure-activity relationship to create in silico models for binding of these compounds into the active site of PfSUB1.
Atslēgas vārdi
inhibitors, malaria, Malaria Box, PfSUB1 protease, quinoxaline
DOI
10.1007/s10593-014-1610-4
Hipersaite
http://link.springer.com/article/10.1007%2Fs10593-014-1610-4
Kher, S., Penzo, M., Fulle, S., Ebejer, J., Finn, P., Blackman, M., Jirgensons, A. Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1. Chemistry of Heterocyclic Compounds, 2015, Vol.50, Iss.10, 1456.-1462.lpp. ISSN 0009-3122. e-ISSN 1573-8353. Pieejams: doi:10.1007/s10593-014-1610-4
Publikācijas valoda
English (en)