Quinoxaline-Based Inhibitors of Malarial Protease Pfsub1

Химия гетероциклических соединений = Khimiya Geterotsiklicheskikh Soedinenii 2014
Samir Satish Kher, M. Penzo, S. Fulle, J. P. Ebejer, P. W. Finn, M. J. Blackman, Aigars Jirgensons

2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds. The synthesis of analog series and investigation of their inhibitory activity provided preliminary structure-activity relationship to create in silico models for binding of these compounds into the active site of PfSUB1.

Atslēgas vārdi
QUINOXALINE-BASED INHIBITORS OF MALARIAL PROTEASE PfSUB1

Kher, S., Penzo, M., Fulle, S., Ebejer, J., Finn, P., Blackman, M., Jirgensons, A. Quinoxaline-Based Inhibitors of Malarial Protease Pfsub1. Химия гетероциклических соединений = Khimiya Geterotsiklicheskikh Soedinenii, 2014, Vol.50, Iss.10, 1583.-1589.lpp. ISSN 0132-6244.

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