Purine Functionalization via Bis-Triazolyl Derivatives
Balticum Organicum Syntheticum: Program and Abstracts
2016
Kristers Ozols,
Dace Cīrule,
Ērika Bizdēna,
Māris Turks
2,6-Diazidopurine deoxyribonucleoside has been employed for synthesis of 2,6-bis-triazolyl derivatives using the Cu(I) catalyzed azide-alkyne cycloaddition. These compounds undergo neat, regioselective and high-yielding reactions with N- and S- nucleophiles. Since the N- products exhibit visible fluorescence, one of the adenosine analogues (λ emission = 420 nm, QY = 12% in water) has been further investigated as a fluorescent label. After incorporation in trinucleotide, 7% fluorescence quantum yield was determined.
Atslēgas vārdi
Purine, Nucleoside, Fluorescent adenosine, Click chemistry, Aromatic substitution
Hipersaite
http://www.boschem.eu/public/BOS2016/BOS-2016_Anstract-Book_Final.pdf
Ozols, K., Cīrule, D., Bizdēna, Ē., Turks, M. Purine Functionalization via Bis-Triazolyl Derivatives. No: Balticum Organicum Syntheticum: Program and Abstracts, Latvija, Rīga, 3.-6. jūlijs, 2016. Riga: 2016, 125.-125.lpp.
Publikācijas valoda
English (en)