Novel Fluorescent Purine Nucleoside-Amino Acid Conjugates

XXII International Round Table on Nucleosides, Nucleotides and Nucleic Acids: Abstract Book 2016
Dace Cīrule, Kristers Ozols, oskars Platnieks, Ērika Bizdēna, Māris Turks

Our group has recently reported the synthesis of 2,6-bis-triazolyl purine nucleosides and their regioselective reactions with primary and secondary amines and thiols. The obtained N6- substituted 2-triazolyl adenosine analogs possessed good fluorescent properties. Thus, we proceeded to investigate purine nucleoside SNAr chemistry which uses 1,2,3-triazole as a leaving group and to study photophysical properties of the obtained purine nucleoside-amino acid adducts.

Atslēgas vārdi
Purine, Nucleosides, Nucleoside-amino acid conjugates, Click chemistry, Fluorescence

Cīrule, D., Ozols, K., Platnieks, O., Bizdēna, Ē., Turks, M. Novel Fluorescent Purine Nucleoside-Amino Acid Conjugates. No: XXII International Round Table on Nucleosides, Nucleotides and Nucleic Acids: Abstract Book, Francija, Paris, 18.-22. jūlijs, 2016. Paris: 2016, 215.-216.lpp.

Publikācijas valoda
English (en)