Leaving-Group Directed SNAr Reactions of 2,6-Disubstituted Purines
20th European Symposium on Organic Chemistry
2017
Kristers Ozols,
Irina Novosjolova,
Dace Cīrule,
Kathrin Helen Hopmann,
Ērika Bizdēna,
Māris Turks
In the well-developed area of purine chemistry there persists a rule of thumb that 6th
position shows elevated reactivity in purines having leaving groups at positions 2 and 6
of the heterocycle. However, it has been reported by Novosjolova et al. that this
reactivity may be switched in 2,6-diazidopurine derivatives[1]. In our present work, 2,6-
disubstituted purine reactivity trends are explored by DFT methods and the utility of
these reactions is demonstrated by the synthesis of 6/2-azido-2/6-alkylthio-purine
derivatives.
Atslēgas vārdi
2,6-Disubstituted Purines
Ozols, K., Novosjolova, I., Cīrule, D., Hopmann, K., Bizdēna, Ē., Turks, M. Leaving-Group Directed SNAr Reactions of 2,6-Disubstituted Purines. No: 20th European Symposium on Organic Chemistry, Vācija, Ķelne, 2.-6. jūlijs, 2017. Cologne: 2017, SY106.-SY106.lpp.
Publikācijas valoda
English (en)