Fluorescent Triazolyl Purines and their Nucleoside Congeners

German-Polish-Baltic Conference on Organic Chemistry : Book of Abstracts 2018
Māris Turks, Ērika Bizdēna, Dace Cīrule, Zigfrīds Kapilinskis, Irina Novosjolova, Kristers Ozols, Armands Sebris, Andrejs Šišuļins, Jānis Miķelis Zaķis

Further investigations lead to the use of diazidopurine as a substrate for SNAr reactions. Depending on the nature of N(9) substituent of purine, the incoming nucleophile and the experimental conditions, selectivity towards differently substituted compounds can be achieved. This is mainly determined by azide-tetrazole tautomerism 1-A ↔ 1-T. We have found that 2-(1,2,3-triazolyl)adenine/adenosine analogs and their regioisomers possess excellent fluorescent properties. These purine derivatives can be applied both for fluorescent oligonucleotide synthesis and for OLED technologies. Moreover, the developed chemistry permits synthesis of novel purine conjugates containing 5-membered heterocycles at C(2).

Atslēgas vārdi
purines, azoles, SNAr reactions
Hipersaite
https://www.chemie.uni-hamburg.de/veranstaltungen/6gpcoc/GBP_Abstracts.pdf

Turks, M., Bizdēna, Ē., Cīrule, D., Kapilinskis, Z., Novosjolova, I., Ozols, K., Sebris, A., Šišuļins, A., Zaķis, J. Fluorescent Triazolyl Purines and their Nucleoside Congeners. No: German-Polish-Baltic Conference on Organic Chemistry : Book of Abstracts, Vācija, Hamburg, 15.-19. maijs, 2018. Hamburg: Hamburger Print Service, 2018, 59.-59.lpp. ISBN 978-3-00-058883-9.

Publikācijas valoda
English (en)