1,2,3-Triazoles as Leaving Groups: SNAr Reactions of 2,6-Bis-triazolyl Purines with O- and C-nucleophiles
Beilstein Journal of Organic Chemistry
2021
Dace Cīrule,
Irina Novosjolova,
Ērika Bizdēna,
Māris Turks
A new approach was designed for the synthesis of C6-substituted 2-triazolylpurine derivatives. A series of substituted products was obtained in SNAr reactions between 2,6-bistriazolylpurine derivatives and O- and C-nucleophiles under mild conditions. The products were isolated in yields up to 87%. The developed C-O and C-C bond forming reactions clearly show the ability of the 1,2,3-triazolyl ring at the C6 position of purine to act as leaving group.
Atslēgas vārdi
2,6-bistriazolyl purines, Nucleophilic aromatic substitution, Purine nucleosides, Triazoles
DOI
10.3762/BJOC.17.37
Hipersaite
https://www.beilstein-journals.org/bjoc/articles/17/37
Cīrule, D., Novosjolova, I., Bizdēna, Ē., Turks, M. 1,2,3-Triazoles as Leaving Groups: SNAr Reactions of 2,6-Bis-triazolyl Purines with O- and C-nucleophiles. Beilstein Journal of Organic Chemistry, 2021, Vol. 17, 410.-419.lpp. ISSN 1860-5397. Pieejams: doi:10.3762/BJOC.17.37
Publikācijas valoda
English (en)