We have developed synthesis of 2,6-bis-triazolyl-purine derivatives 4 (Y = 1,2,3-triazole) and demonstrated their application in SNAr reactions by substituting C(6) position of purine with a broad range of N-, S-, Se-, C-, O-, and P-nucleophiles (Scheme 1).[1] 2,6-Bis-triazolyl-purine derivatives 4 and their SNAr products 5 are fluorescent and this has led to development of ion sensing, cell imaging systems and applications in materials science.[2] On the other hand, azidosubstituted fused pyrimidines of type 2 exhibit azide-tetrazole tautomerism, which was instrumental to develop novel substitution methodologies (nucleophile-nucleofuge dance) around the cycle[3] and also pyrimidine ring opening reactions leading to compounds of type 3