Up to now the development scenarios of Latvian energy and fuel balance were mainly designed for the national level. However in the regional level there are significant differences both in energy consumption and fuel resources used. For the simulation and comparison of different energy development scenarios, MESAP (Modular Energy System Analysis and Planning) software, allowing making calculations at national and regional level without changing the structure of the model, was used. To perform a detailed regional modelling, Latvia was split in 6 regions, each having a separate forecasted electricity, thermal energy and fuel final consumption. For the regional modelling, similar RES structure to overall Latvian energy balance development options simulation was used. Three development scenarios in the regional level have been simulated: base scenario (I), scenario of maximal use of renewable energy resources and domestic energy resources (II) and maximum production of electrical energy and fuel diversification scenario (III). The choice of scenarios can be substantiated with a necessity to promote usage of renewable energy resources, as well as with decrease of electricity imports proportion in the energy balance of Latvia. The simulation results show, that the increasing demand of energy can be covered in several ways – by continuing to import power, maximally using the renewable and local energy resources, as well as using coal and biomass mix for the production of electricity.