Site Selective C(Sp3)-H Arylation of Pentacyclic Triterpenoids
24th Tetrahedron Symposium: Book of Abstracts 2024
Viktors Kumpiņš, Vladislavs Kroškins, Jevgeņija Lugiņina, Māris Turks

Naturally abundant pentacyclic triterpenoids are significant secondary metabolites which have aroused huge interest by possessing wide range of remarkable biological activities such as antitumor[1] antidiabetic[2] anti-inflammatory[3] and antiviral activities[4]. Oleanolic, ursolic acids and betulin are the most prominent compounds of this branch, which are isolated from various plants. The aim of this work is to obtain novel triterpenoid derivatives by C-H arylation at C(22). For this purpose, precursors bearing picolinic amide directing groups were synthesized.


Atslēgas vārdi
C-H arilēšana, pentacikliskie triterpenoīdi

Kumpiņš, V., Kroškins, V., Lugiņina, J., Turks, M. Site Selective C(Sp3)-H Arylation of Pentacyclic Triterpenoids. No: 24th Tetrahedron Symposium: Book of Abstracts, Francija, Montpellier, 18.-21. jūnijs, 2024. Montpellier: 2024, 243.-243.lpp.

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