Although energetic materials are some of the most influential materials in human history their modern evolution has been relatively slow. Energetic materials must achieve a challenging combination of properties including high explosive power, high stability and low cost, therefore new strategies for their synthesis are required.1 Recently co-crystallization has emerged as a new method for generating novel forms of energetic materials. Co-crystallization can increase density, improve thermal stability and decrease the sensitivity of energetic materials.2 Co-crystals of many energetic materials have been reported, however little to no work has been done on designed intermolecular bonding for these materials. We will discuss the use of energetically modified nucleobases such as adenine and uracil derivatives in the formation of Watson-Crick type bonded insensitive energetic materials co-crystals and study their properties