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Publikācija: Calcium Phosphate Bioceramics Prepared by Wet Chemical Precipitation Route

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Nosaukums oriģinālvalodā Calcium Phosphate Bioceramics Prepared by Wet Chemical Precipitation Route
Pētniecības nozare 2. Inženierzinātnes un tehnoloģijas
Pētniecības apakšnozare 2.4. Ķīmijas inženierzinātne
Autori Kristīne Šalma-Ancāne
Līga Bērziņa-Cimdiņa
Natālija Borodajenko
Atslēgas vārdi calcium phosphates, hydroxyapatite, β-tricalcium phosphate, wet chemical precipitation synthesis
Anotācija Due to excellent biocompatibility with living body and bioactivity, calcium phosphate (CaP) ceramics (hydroxylapatite [HAp, Ca10(PO4)6(OH)2)], β-tricalcium phosphate [β-TCP, Ca3(PO4)], biphasic calcium phosphates [BCP, β-TCP + HA]) are widely used as biomedical implant materials. Biomaterials and bioceramic made of calcium phosphates are produced in different forms: granules, blocks (dense or porous), injectable compositions, self-hardening cements, coatings on metallic implants, composites from polymers, and so forth. Various synthesis routes have been developed for the preparation of calcium phosphates, which must present desirable characteristics, such as, stoichiometry of synthesis product, crystallinity, particle size, morphology and specific surface area. Calcium phosphate characteristics significantly influence CaP bioceramic properties, such as, definite phase and chemical composition, sinterability, thermal stability, fine and homogenous microstructure, biomechanical properties and then cellular response in living body. In this work calcium phosphates were synthesized by modified wet chemical precipitation route. Contrary to the conventional chemical precipitation route calcium hydroxide was homogenized with planetary mill to obtain homogenous synthesis product without impurities such as CaO. The aim of this work was to study the influence of main processing parameters of wet chemical precipitation synthesis product and to control not only the phase and chemical composition, but also thermal stability and microstructure of calcium phosphate bioceramics. The results showed that it is possible to obtain calcium phosphates with different and reproducible phase compositions (HAp, β-TCP and HAp/β-TCP) by modified wet-chemical precipitation route. The β-TCP content in HAp powder is found to be highly dependent on the changes in technological parameters and it can be controlled with ending pH, synthesis temperature, aging time of suspension and thermal treatment. Pure, crystalline and highly thermally stable (up to 1300ºC) HAp bioceramic with homogenous grainy microstructure, grain size up to 200-250 nm and high open porosity can be successfully synthesized by elevating synthesis temperature to 70ºC, stabilizing ending pH at 9 and aging time of suspension at 20 h.
Atsauce Šalma-Ancāne, K., Bērziņa-Cimdiņa, L., Borodajenko, N. Calcium Phosphate Bioceramics Prepared by Wet Chemical Precipitation Route. No: VIII Students' Meeting "Processing and Application of Ceramics", Serbija, Novi Sad, 2.-5. decembris, 2009. Novi Sad: University of Novi Sad, 2009, 50.-51.lpp.
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