Strontium and Strontium Ranelate: Historical Review of Some of Their Functions

Materials Science and Engineering: C 2017
Māra Pilmane, Kristīne Šalma-Ancāne, Dagnija Loča, Jānis Ločs, Līga Bērziņa-Cimdiņa

The review covers historical and last decade's scientific literature on the biological and clinical role of strontium (Sr) and strontium ranelate (Sr RAN). It enrols the description of the main effects of Sr on supportive tissue, its proven and possible morphopathogenetical mechanisms and the interaction with the bone, and especially focuses on the Sr ability to inhibit osteoclasts and affect the programmed cell death. The main experimental and clinical experience regarding the Sr RAN influence in the treatment of osteoporosis and the search for correct doses is also highlighted. The review gives insight into the role of Sr/Sr RAN on stem cells, apoptosis, animal and clinical research.

Keywords
Strontium, Strontium ranelate, Physiology, Bone Medicine
DOI
10.1016/j.msec.2017.05.042
Hyperlink
http://www.sciencedirect.com/science/article/pii/S0928493116319488?via%3Dihub

Pilmane, M., Šalma-Ancāne, K., Loča, D., Ločs, J., Bērziņa-Cimdiņa, L. Strontium and Strontium Ranelate: Historical Review of Some of Their Functions. Materials Science and Engineering: C, 2017, Vol.78, pp.1222-1230. ISSN 0928-4931. Available from: doi:10.1016/j.msec.2017.05.042

Publication language
English (en)