The Regional Skill Councils Blueprint report aims to facilitate understanding, identifying, and developing 21st-century skills through multi-stakeholder collaborative efforts in region-specific and labour-market-relevant contexts. The report details the modalities and aspects of setting up a successful diverse multi-stakeholder constellation tasked with assessing and developing 21st-century skills guided by the labour market needs, technology trends and any differences stemming from gender. A blueprint for stakeholder engagement is a model for cooperation between higher education institutions and employers, provides a clear roadmap of engagement opportunities and potential action for all involved higher education and industry stakeholders.