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Publikācija: Lidocaine Loaded Ca/P Scaffolds for Bone Regeneration and Local Drug Delivery

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Nosaukums oriģinālvalodā Lidocaine Loaded Ca/P Scaffolds for Bone Regeneration and Local Drug Delivery
Pētniecības nozare 2. Inženierzinātnes un tehnoloģijas
Pētniecības apakšnozare 2.5. Materiālzinātne
Autori Dagnija Loča
Jānis Ločs
Juris Gulbis
Ilze Šalma
Līga Bērziņa-Cimdiņa
Atslēgas vārdi bioceramics, drug delivery, hydroxyapatite, calcium phosphate ceramics,
Anotācija Local drug delivery devices especially based on osteoconductive porous calcium phosphate ceramics are of clinical importance. However, the brittleness, pore structure, porosity and pore size should be controlled for their wider applications in hard tissue implants and load bearing compartments. An approach to the fabrication of the bone graft exhibiting bone regeneration function as well as the local drug delivery was made. Hydroxyapatite (HAp)/β-tricalcium phosphate (β-TCP) porous scaffolds were prepared and mechanical properties (compression strength 20MPa), porosity (>50%), pore size (60-350μm) and structure as well as interconnectivity of pores were investigated. Porous scaffolds were impregnated with 4-5 mg of lidocaine hydrochloride (LidHCl) and drug release rate was evaluated and compared for scaffolds with and without poly lactic acid (PLA), poly( -caprolactone) (PCL) and polyvinyl alcohol (PVA) coatings. From in vitro dissolution tests it was seen that biopolymer coatings sustained the drug release up to 12h.
DOI: 10.4028/www.scientific.net/AMR.222.289
Hipersaite: http://www.scientific.net/AMR.222.289 
Atsauce Loča, D., Ločs, J., Gulbis, J., Šalma, I., Bērziņa-Cimdiņa, L. Lidocaine Loaded Ca/P Scaffolds for Bone Regeneration and Local Drug Delivery. Advanced Materials Research, 2011, Vol.222, 289.-292.lpp. ISSN 1022-6680. Pieejams: doi:10.4028/www.scientific.net/AMR.222.289
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